Publications by authors named "H Terpstra"
Fluorescence microscopy has revolutionized biological research by enabling the visualization of subcellular structures at high resolution. With the increasing complexity and volume of microscopy data, there is a growing need for automated image analysis to ensure efficient and consistent interpretation. In this study, we introduce PunctaFinder, a novel Python-based algorithm designed to detect puncta, small bright spots, in raw fluorescence microscopy images without image denoising or signal enhancement steps.
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- FOXO1, a transcription factor influenced by insulin signaling, is shown to prevent aggregation of toxic polyglutamine proteins associated with certain diseases.
- Increasing FOXO1 levels in human cells reduces the risk of polyQ aggregation, while decreasing its levels accelerates this process.
- The protective effect of FOXO1 operates independently from typical degradation pathways, as it lowers the synthesis of proteins from harmful CAG repeat transcripts, thus improving protein balance and reducing potential toxicity in CAG-repeat disorders.
In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain constant during G1, due to the presumed scaling of its production rate with cell size dynamics. Measuring metabolic and biosynthetic activity during cell cycle progression in single cells, we found that cells exhibit pulses in their protein production rate.
View Article and Find Full Text PDFElectronic structure of beta -PbO2 and its relation with BaPbO3.
Phys Rev B Condens Matter
October 1995