Publications by authors named "H Teraoka"
To study the effects of drugs on embryo/fetal development (EFD), developmental and reproductive toxicity studies in zebrafish () embryos is expected to be an accepted alternative method to animal studies using mammals. However, there is a lack of clarity in the relationship between the concentration of developmental toxicity agents in whole embryos or larvae (Ce) and that in aqueous solution (Cw), and also between the amount of drug exposure required to cause developmental toxicity in zebrafish embryos or larvae and that required in mammals. Here, we measured Ce for developmental toxicity agents every 24 h starting at 24 h post fertilization (hpf).
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- Non-coplanar PCBs (like Aroclor 1254) and PBDEs (such as BDE-47) are harmful to neurogenesis and neuronal development in zebrafish.
- Previous findings showed these chemicals increase zebrafish movement by reducing dopamine levels.
- The study found that inhibiting the enzyme tyrosinase, important for melanin production, not only decreased pigmentation but also reduced the hyperactivity caused by PCB/PBDE exposure, suggesting a link between melanin and dopamine production affected by these toxins.
Red-crowned cranes () consist of two distinct groups: the continental population and the island population. The island population, localized in Hokkaido, Japan, exhibits very low genetic diversity due to its rapid recovery from the brink of extinction. Our previous research in 2018 highlighted a possible mating between a male from the continental population, with the Gj5 haplotype, and a female from the island population, with the Gj2 haplotype, at Hitominuma Sawmp shore in northern Hokkaido.
View Article and Find Full Text PDFCase 1: A 48-year-old woman, had right breast cancer with multiple liver metastases. Seven courses of paclitaxel plus bevacizumab were administered, but due to disease progression, 12 courses of FEC 75(total epirubicin 900 mg/m2)were administered. 2 months after the last FEC administration, the patient developed heart failure and died about 3 months later.
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