Publications by authors named "H Ten Cate"
Introduction: Unfolded Von Willebrand Factor (VWF) is increased in thrombotic pathologies such as myocardial infarction. Unfolded VWF mediates the binding of platelets without the need for collagen. β-glycoprotein I (β-GPI) is a natural inhibitor of the platelet-VWF interaction.
View Article and Find Full Text PDFArterial and venous thromboembolism are leading causes of morbidity and death worldwide. Despite significant advances in the diagnosis, prognostication, and treatment of thrombotic diseases over the past 3 decades, the adoption of findings stemming from translational biomarker research in clinical practice remains limited. Biomarkers provide an opportunity to enhance our understanding of pathophysiological processes and optimize treatment strategies.
View Article and Find Full Text PDFBackground: Early detection and diagnosis of venous thromboembolism are vital for effective treatment. To what extent methodological shortcomings exist in studies of diagnostic tests and whether this affects published test performance is unknown.
Objectives: We aimed to assess the methodological quality of studies evaluating diagnostic tests for venous thromboembolic diseases and quantify the direction and impact of design characteristics on diagnostic performance.
Article Synopsis
- Managing cancer-associated thrombosis (CAT) poses challenges due to factors like bleeding risk, patient frailty, and drug interactions, necessitating careful treatment decisions.
- With the introduction of direct oral anticoagulants (DOACs), not all CAT patients benefit equally due to varied clinical and laboratory characteristics.
- This review discusses four specific scenarios in CAT management—brain metastasis, gastrointestinal malignancies, drug interactions, and thrombocytopenia—suggesting tailored treatment approaches based on current literature.