Publications by authors named "H Tayebi"
Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity compartments to play several roles in tumour progression. Tumour-associated macrophages (TAMs), one of the most dominant components in the tumour microenvironment, are recognized as anti-tumour suppressors.
View Article and Find Full Text PDFBackground: An individual's genetic fingerprint is emerging as a pivotal predictor of numerous disease- and treatment-related factors. Single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes play key roles in an individual's exposure to a malignancy-associated risk, such as Aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC).
Aim: This study aimed at reviewing literature on the polymorphisms that exist in CYP enzymes and their possible link with susceptibility to AFB1-induced HCC.
Article Synopsis
- Multiple sclerosis (MS) is a chronic condition characterized by the deterioration of nerve insulation, and the study aimed to assess the effectiveness of metformin combined with interferon beta 1a in patients with relapsing-remitting MS.
- Eighty patients were divided into two groups: one received metformin with IFNβ-1a, while the other only received IFNβ-1a. After six months, no significant differences were found between the two groups in several measured outcomes, including inflammatory markers and disability status.
- Although the addition of metformin showed a potential effect on reducing levels of an oxidative stress marker (MDA), the overall immunological and clinical outcomes did not demonstrate significant