Anti-Biofilm Performance of Resin Nanopillars Inspired from Cicada Wing Surface for spp.

The increase in infections derived from biofilms from spp. prompted us to develop novel strategies to inhibit biofilm development. Nanoscale protrusion structures (nanopillars) observed on the wings of dragonflies and cicadas have recently gained notable attention owing to their physical, antimicrobial, and bactericidal properties.

Differential effects of imeglimin and metformin on insulin and incretin secretion-An exploratory randomized controlled trial.

Aims: Imeglimin is a new oral anti-diabetic drug with a similar structure to that of metformin; however, unlike metformin, clinical trials indicate that imeglimin elicits its glucose-lowering effect mainly by enhancement of insulin secretion. The comparative effects of the two drugs on incretin secretion remains to be elucidated.

Materials And Methods: A single-center, open-label, randomized controlled trial was conducted in patients with type 2 diabetes who were drug-naïve or were on a single oral hypoglycaemic agent (OHA).

Antimicrobial Activity of Positively Charged Oligopeptides with Theoretical High α-Helix Content against .

is abundant and commonly exists as a superficial bacteria on human skin. Recently, the resistance of to antimicrobial agents has become a serious concern, necessitating the development of alternative pharmaceutical products with antimicrobial activity against . To address this need, we evaluated the antimicrobial activity of CKR-13-a mutant oligopeptide of FK-13 with increased net charge and theoretical α-helical content-against in modified Gifu Anaerobic Medium broth by determining the minimum inhibitory concentration (MIC).

To treat or not to treat: Assessing the role of anti-enterococcal therapy for intra-abdominal infections in patients with cancer.

The clinical significance of enterococci in intra-abdominal infections, particularly those caused by multiple organisms, remains unclear. There are no definitive guidelines regarding the use of empiric therapy with antimicrobial agents targeting enterococci. In this study, we evaluated the impact of the initial antimicrobial therapy administration of anti-enterococcal agents on the treatment of intra-abdominal infections in patients with cancer in whom enterococci were isolated from ascitic fluid cultures.