Publications by authors named "H Tarumi"
Article Synopsis
- Epidermal growth factor receptor (EGFR)-mutated squamous cell carcinoma (SCC) is rare compared to adenocarcinoma, and the effectiveness of osimertinib, a treatment known to work for adenocarcinoma, is uncertain for SCC.
- An 83-year-old male with EGFR exon19 deletion SCC treated with osimertinib experienced disease progression after 18 days, leading to his death three weeks later.
- Autopsy and next-generation sequencing indicated the presence of other genetic mutations (TP53 R158L, CDK6, and KRAS amplifications), suggesting these could explain osimertinib's failure in his case.
Previously, we have reported that sealants incorporating bisphenol A dimethacrylate showed estrogenicity by a reporter gene assay. This study tested the hypothesis that commercial composites, which contain various monomers and additives, exhibit estrogenic activity in vitro. The estrogenic activities of eluates obtained from 24 composites and 18 chemicals identified from the composites tested were examined with the use of the reporter gene assay.
View Article and Find Full Text PDFObjectives: The aims of this study were to investigate the antibacterial activity of an adhesive resin incorporating the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) as well as its bonding characteristics in terms of bond strength into dentin and curing ability.
Methods: An experimental adhesive resin was prepared by incorporation of 2.5% MDPB into proprietary adhesive (LB Bond), and the inhibitory effect of cured specimen against the growth of Streptococcus mutans on its surface was determined.
Objective: Differential thermal analysis (DTA) using a split fiber optic light source has been reported to be a convenient method of measuring the degree of conversion (DC) of light-activated composites. The purpose of this study was to compare the results by DTA and Fourier transformation infrared spectroscopy (FTIR), and evaluate the usefulness of the DTA method.
Methods: Experimental 2,2-bis[4-(3-methacryloyloxy-2-hydroxypropoxy)phenyl]propane-based composites containing SiO2 filler and various amounts of triethyleneglycol dimethacrylate (TEGDMA) were prepared, and the DC of each composite was determined by DTA or FTIR with 60s irradiation.
It is controversial whether the dental resinous materials containing 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (Bis-GMA), which is synthesized from the estrogenic compound bisphenol A (BPA), include unreacted BPA and/or can mimic the effects of natural steroid hormones. In the present study, the estrogenic activities of 3 fissure sealants and 5 adhesive resins, which were all unpolymerized, were determined by means of a reporter gene assay, and the relevance of the components to the estrogenicity was investigated. Two commercially available sealants were confirmed to have estrogenic activity, although none of the tested materials contained BPA.
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