Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer.

Background: Polypharmacology means drugs having interactions with multiple targets of a unique disease or many disease pathways. This concept has been greatly appreciated against complex diseases, such as oncology, CNS disorders, and anti-infectives.

Methods: The integration of diverse compounds available on public databases initiates polypharmacological drug discovery research.

Exploring the SARS-Cov-2 Main Protease (M) and RdRp Targets by Updating Current Structure-based Drug Design Utilizing Co-crystals to Combat COVID-19.

The unprecedented pandemic of COVID-19 caused by the novel strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) engulfs millions of death worldwide. It has directly hit the socio-economic status of the affected countries. There are more than 219 countries badly affected by the COVID-19.

Repositioning of RdRp Inhibitors Against HCV NS5B Polymerase Utilizing Structure-Based Molecular Docking.

Objective: Hepatitis C Virus (HCV) is very dreadful as it can attack an estimated 71 million people around the world. The World Health Organization (WHO) reported that every year about 399000 people die due to HCV caused by chronic cirrhosis and liver cancer globally. There are many drugs available for the treatment of HCV.

To Explore the Potential Targets and Current Structure-based Design Strategies Utilizing Co-crystallized Ligand to Combat HCV.

Background: Hepatitis C Virus (HCV) belongs to the Hepacivirus family. HCV has been designated as a very dreadful virus as it can attack the liver, causing inflammation and even may lead to cancer in chronic conditions. It was estimated that 71 million people around the world have chronic HCV infection.

Adsorption and oxidation of aromatic amines by metal hexacyanoferrates(II).

Interaction of aniline, p-toluidine and p-chloroaniline with nickel, cadmium and manganese hexacyanoferrates(II) has been studied. Nickel and cadmium hexacyanoferrates(II) showed maximum adsorption at neutral pH, whereas, manganese hexacyanoferrate(II) reacts with aniline, p-toluidine and p-chloroaniline forming the colored oligomers on its surface. The adsorption data obtained at neutral pH is fitted in Langmuir adsorption isotherm.