Publications by authors named "H Tankisi"
Article Synopsis
- The study investigates neuromuscular junction (NMJ) function in patients with Charcot-Marie Tooth (CMT) disease and explores the potential for improving muscle strength through ClC-1 channel inhibition.
- Results showed significant NMJ abnormalities in CMT patients, such as increased jitter and blocking, which correlated with weaker muscle performance and endurance.
- Preclinical experiments indicated that a new drug, NMD670, improved muscle strength and endurance in CMT mice, suggesting that targeting NMJ dysfunction might offer a new therapeutic approach for CMT patients.
Introduction/aims: MScanFit motor unit number estimation (MUNE) is the most recent MUNE method which has shown promising results in extremity muscles, but it has not been applied to bulbar muscles. Bulbar muscles are particularly important in the diagnosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate the feasibility and reliability of MScanFit MUNE in the accessory nerve and trapezius muscles.
View Article and Find Full Text PDFBackground And Objectives: There is a need for knowledge regarding the natural course of diabetic polyneuropathy (DPN), a complication in type 2 diabetes (T2D). The aim of this study was to examine the development of DPN over time.
Methods: Patients with newly diagnosed T2D, recruited from a national cohort, and controls without diabetes of similar age and sex, underwent sensory phenotyping in 2016-2018.
Objective: There is a need for sensitive biomarkers in amyotrophic lateral sclerosis (ALS), to enable earlier diagnosis and to help assess potential treatments. The main objective of this study was to compare two potential biomarkers, threshold-tracking short-interval cortical inhibition (T-SICI), which has shown promise as a diagnostic aid, and neurofilament light chains (NfL).
Methods: Ninety-seven patients with ALS (mean age 67.