Analysis of Bevacizumab-Induced Gastrointestinal Perforation Using the Japanese Adverse Drug Event Report Database.

Introduction: Bevacizumab is a recombinant humanized monoclonal antibody against human vascular endothelial growth factor (VEGF), which inhibits angiogenesis in tumor tissues by blocking VEGF activity. Although rare, bevacizumab-induced gastrointestinal perforation (BIGP) can reduce patients' quality of life and even lead to death. We aimed to evaluate the time to BIGP onset according to the indication, its outcome, and the effect of bevacizumab in combination with various anticancer agents.

A feasible treatment strategy for tapering subcutaneous tocilizumab in giant cell arteritis: a 24-month multi-center retrospective study.

To examine whether extending tocilizumab (TCZ) intervals is a feasible treatment strategy in giant cell arteritis (GCA). This multicenter retrospective study included patients with GCA who started subcutaneous TCZ at five Japanese hospitals between January 2008 and July 2021. We collected clinical data and monitored relapses for up to 24 months following the initiation of TCZ.

Self-Organizing Map-Based Assessment of Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors.

Introduction Remarkable progress has been made in the field of cancer therapy in recent years owing to the development of immune checkpoint inhibitors (ICIs); however, controlling immune-related adverse events (irAEs) remains challenging for treatment completion. This is the first study to visualize the irAE profiles of ICIs using self-organizing maps (SOM) and to combine this with decision tree analysis. The purpose of this study is to identify adverse events from a wide variety of irAEs in eight ICIs that can be useful for early detection.

Evidence for the Worldwide Distribution of a Bile Salt Hydrolase Gene in Through Horizontal Gene Transfer.

Bile salt hydrolase (BSH), a probiotic-related enzyme with cholesterol-assimilating and anti-hypercholesterolemic abilities, has been isolated from intestinal bacteria; however, BSH activity of bacteria in bile-salt-free (non-intestinal) environments is largely unknown. Here, we aimed to identify BSH from non-intestinal and characterize its enzymatic function. We successfully isolated a plasmid-encoded () from , and the recombinant EfpBSH showed BSH activity that preferentially hydrolyzed taurine-conjugated bile salts, unlike the activity of known BSHs.

Overexpression of the RNA-binding protein NrdA affects global gene expression and secondary metabolism in species.

RNA-binding protein Nrd1 plays a role in RNA polymerase II transcription termination. In this study, we showed that the orthologous NrdA is important in global mRNA expression and secondary metabolism in species. We constructed an conditional expression strain using the Tet-On system in mut.