Publications by authors named "H TAKEZAWA"

Article Synopsis
  • The study introduces a new approach to improve organic macrocyclic hosts by enclosing them in a larger ML cage, creating host-in-host complexes.
  • The macrocyclic hosts, like cyclotriveratrylene and calix[8]arene, benefit from enhanced orientations which boost their ability to recognize other molecules.
  • The structural analysis through X-ray techniques allows for observation of how these hosts encapsulate guest molecules within the highly crystalline ML cage.
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The ML cage, self-assembling from six Pd(II) or Pt(II) 90-degree blocks and four triazine-cored triangular ligands, has an effective hydrophobic cavity of about 450 Å capable of encapsulating one or more small molecules. Here, from the same components, we successfully constructed an ML cage with an internal volume expanded to 1540 Å via the self-assembly of an ML precursor using pillar[5]arene as a template. This cage retains the high molecular recognition ability of the ML cage while recognizing medium-sized guest molecules with molecular weights of up to ∼1600.

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Background: Carotid artery stenting (CAS) is commonly performed to treat internal carotid artery (ICA) stenosis;however, it is associated with high recurrence rates. The treatment of in-stent restenosis (ISR) following CAS poses several challenges, and percutaneous transluminal angioplasty (PTA) is a possible treatment option. Scoring balloons used in the cardiovascular field can prevent slipping and plaque incisions during balloon expansion;however, their efficacy in treating cervical ICA ISR remains uncertain.

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Background: Treatment of chronic subdural hematoma (CSDH) with middle meningeal artery embolization (MMAE) is becoming well established. Transradial artery access (TRA) is considered less invasive than transfemoral artery access (TFA) and is increasingly indicated in the field of endovascular therapy. Therefore, this study focused on postoperative delirium and compared access routes.

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