Relative blood volume changes underestimate total blood volume changes during hemodialysis.

Background: Measurements of relative blood volume changes (DeltaRBV) during hemodialysis (HD) are based on hemoconcentration and assume uniform mixing of erythrocytes and plasma throughout the circulation. However, whole-body hematocrit (Ht) is lower than systemic Ht. During HD, a change in the ratio between whole-body to systemic Ht (F cell ratio) is likely to occur as a result of a net shift of low Ht blood from the microcirculation to the macrocirculation.

Preclinical characterisation of 111In-DTPA-trastuzumab.

Trastuzumab (Herceptin) is a recombinant humanised IgG1 monoclonal antibody against the human epidermal growth factor receptor 2 (HER2), used for metastatic breast cancer treatment. Radiolabelled trastuzumab may have several future applications for diagnostic use. The aim of the present study was to develop clinical grade (111)Indium ((111)In) radiolabelled trastuzumab, to evaluate the stability and immunoreactivity of the tracer and to perform a biodistribution study in human tumour-bearing mice.

Measurement of higher-order mode attenuation in single-mode fibers: effective cutoff wavelength.

A technique for the determination of the wavelength-dependent attenuation coefficient of the LP(11) mode in sing]emode fibers is presented. Knowledge of the magnitude of this coefficient is required, e.g.