Association of Serum Uric Acid Level With Bone Mineral Density and the Risk of Osteoporosis: A Dose-Response Meta-Analysis.

Objective: Serum uric acid (SUA) may play positive roles in diseases associated with oxidative stress, such as osteoporosis (OP). Nevertheless, the specific impact of SUA levels on both bone mineral density (BMD) and the risk of OP remains uncertain. Considering such information crucial for clinicians when making decisions about urate-lowering therapy (ULT), we sought to fill this gap by conducting dose-response meta-analyses.

Evaluating iron deposition in gray matter nuclei of patients with acute ischemic stroke using quantitative susceptibility mapping.

Objectives: Understanding the microscopic pathophysiological mechanisms underlying acute ischemic stroke (AIS) is vital for facilitating early clinical diagnosis and intervention. In this study, we aimed to quantitatively assess brain iron changes in gray matter (GM) nuclei in patients with AIS via quantitative susceptibility mapping (QSM).

Methods: Thirty-four patients with AIS and thirty age-and sex-matched healthy controls (HCs) were included.

[WWP1 plays a positive role in ameloblast differentiation and enamel formation in mice].

To investigate the role of WW domain containing E3 ubiquitin protein ligase 1 (WWP1) in enamel development of mice. Single-cell RNA sequencing data of incisor tissues of postnatal day 7 (P7) mice and mandibular first molar tooth germs of P3.5 mice were used to analyze the expression of WWP1 in dental epithelial cells.

Emerging phospholipid-targeted affinity materials for extracellular vesicle isolation and molecular profiling.

Extracellular vesicles (EVs) carrying lipids, proteins, nucleic acids and small molecular metabolites have emerged as an attractive paradigm for understanding and interfering physiological and pathological processes. To this end, selective and efficient separation approaches are highly demanded to obtain target EVs from complicated biosamples. With increasing knowledges on EV lipids, recent years have witnessed rapid advances of phospholipid-targeted affinity materials and platforms for high-performance isolation and analysis of EVs.

Plaque Stabilization and Regression, from Mechanisms to Surveillance and Clinical Strategies.

With advances in therapies to reduce cardiovascular events and improvements in coronary imaging, an increasing number of clinical trials have demonstrated that treatments to reduce cardiovascular events in coronary artery disease are associated with favorable effects on atherosclerotic plaque size and characteristics. It has been observed that various drugs may induce plaque regression and enhance plaque stability after plaque formation. Numerous clinical trials have been conducted to verify the occurrence of plaque stabilization and regression and their beneficial effects on cardiovascular events.