Publications by authors named "H T Cline"
Amphibians, by virtue of their phylogenetic position, provide invaluable insights on nervous system evolution, development, and remodeling. The genetic toolkit for amphibians, however, remains limited. Recombinant adeno-associated viral vectors (AAVs) are a powerful alternative to transgenesis for labeling and manipulating neurons.
View Article and Find Full Text PDFIdentification of movie encoding neurons enables movie recognition AI.
Proc Natl Acad Sci U S A
November 2024
Article Synopsis
- The study investigates how the visual system processes and integrates information from short movie clips (200-600 ms), revealing that neurons in the optic tectum can detect these movie durations based on experiences and use a hierarchical algorithm to tune responses.
- Through reverse correlation analysis, researchers found that these neurons respond to families of image sequences and suggest that repetitive circuit motifs in the brain are key to movie detection, drawing parallels between frog brain function and machine learning.
- A machine learning network called MovieNet was developed to mimic these natural encoding principles, outperforming existing image recognition models by more efficiently classifying natural movie scenes with reduced data requirements.
tadpoles exhibit an avoidance behavior when they encounter a moving visual stimulus. A visual avoidance event occurs when a moving object approaches the eye of a free-swimming animal at an approximately 90-degree angle and the animal turns in response to the encounter. Analysis of this behavior requires tracking both the free-swimming animal and the moving visual stimulus both prior to and after the encounter.
View Article and Find Full Text PDFArticle Synopsis
- PAR1 is a key receptor linking blood coagulation and obesity-related liver issues, with specific mutations affecting its signaling pathways in mice.
- High-fat diet experiments on different mice strains revealed that while the R41Q mutation reduced liver fat, the R46Q mutation increased liver weight and fat, showing mutations influence liver health differently.
- Treatment with the PAR1 modulator NRD-21 demonstrated benefits by reducing inflammation and liver fat while improving insulin resistance, highlighting potential therapeutic targets for metabolic diseases linked to obesity.