Aging disrupts the link between network centrality and functional properties of prefrontal neurons during memory-guided behavior.

The prefrontal cortex (PFC) is vital for higher cognitive functions and displays neuronal heterogeneity, with neuronal activity varying significantly across individual neurons. Using calcium imaging in the medial PFC (mPFC) of mice, we investigate whether differences in degree centrality-a measure of connectivity strength within local circuits-could explain this neuronal diversity and its functional implications. In young adults, neurons with high degree centrality, inferred from resting-state activity, exhibit reliable and stable action-plan selectivity during memory-guided tasks, suggesting that connectivity strength is closely linked to functional heterogeneity.

DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders.

BCL11B is a Cys2-His2 zinc-finger (C2H2-ZnF) domain-containing, DNA-binding, transcription factor with established roles in the development of various organs and tissues, primarily the immune and nervous systems. BCL11B germline variants have been associated with a variety of developmental syndromes. However, genotype-phenotype correlations along with pathophysiologic mechanisms of selected variants mostly remain elusive.

Comparison of individually packed metalwork and on-the-tray metalwork: A review of clinical risks.

The use of metalwork, such as screws and plates, is common in orthopaedic trauma surgery, with a recent trend towards individually packed metalwork owing to concerns about sterilization efficacy and traceability. Despite this, there is no clinical evidence proving clinical risk from repeat sterilization of metalworks used in orthopaedic trauma of either increased infection rates or loosening or implant failure. On the contrary, the use of individually packed metalworks presents several practical challenges, including higher costs, increased risks of contamination, longer operative times and a larger carbon footprint.

Correction: hERG channel agonist NS1643 strongly inhibits invasive astrocytoma cell line SMA-560.

[This corrects the article DOI: 10.1371/journal.pone.

The CoNi@C/MoC i-MXene Derived from Novel (MoR)GaC (R = Dy, Ho, Er, Tm, and Lu) Nanolaminations for Electrochemical Application in Electrocatalytic Hydrogen Evolution and Supercapacitance.

2D MoC i-MXene is highly promising for electrochemical applications. Here, a synthetic strategy is reported, enabling the uniform distribution of carbon-coated CoNi (CoNi@C) nanoparticles on the vacancy-ordered MoC i-MXene nanosheets, thereby fully exposing the active sites of CoNi@C. First, five novel Ga-containing (MoR)GaC (R = Dy, Ho, Er, Tm, and Lu) i-MAX phases are synthesized as the precursor and found to be crystallized into Cmcm structure, followed by hydrothermal etching and delamination.