Publications by authors named "H T Carisa Le-Petross"
Purpose: Radiation therapy is an underinvestigated tool for priming the immune system in intact human breast cancers. We sought here to investigate if a preoperative radiation therapy boost delivered was associated with a significant change in tumor-infiltrating lymphocytes (TILs) in the tumor in estrogen receptor positive, HER2Neu nonamplified breast cancers.
Methods And Materials: A total of 20 patients were enrolled in a phase 2 clinical trial and received either 7.
Article Synopsis
- The FDA has made changes to improve patient education and safety regarding breast implants, including recalling certain devices and updating screening recommendations for silicone implant ruptures.
- Radiologists need to stay informed about various types of implants, breast reconstruction techniques, and how to image complications associated with implants.
- A key update is the FDA's acceptance of ultrasound as a screening method for silicone implant rupture, which could impact clinical practices significantly.
Article Synopsis
- Early prediction of response to neoadjuvant systemic therapy (NAST) in patients with triple-negative breast cancer (TNBC) can help tailor treatments and prevent unnecessary side effects from ineffective therapies.
- The study analyzed 163 TNBC patients using dynamic contrast-enhanced MRI to identify radiomic features that could indicate treatment response, focusing on areas around and within the tumors at different treatment stages.
- Results showed promising predictive capabilities with certain radiomic features, as well as multivariate models, demonstrating significant accuracy in distinguishing between patients who achieved pathologic complete response (pCR) and those who did not, potentially enhancing early, non-invasive treatment assessments.
Article Synopsis
- Accurate tumor segmentation is essential for analyzing tumors in quantitative imaging studies, particularly for triple-negative breast cancer.
- A new automated deep learning model was developed that uses a comprehensive set of dynamic contrast-enhanced MRI images taken at different stages of treatment.
- This advanced model achieved a high Dice similarity coefficient of 93% and sensitivity of 96%, demonstrating its effectiveness in producing precise tumor measurements for clinical use.
Article Synopsis
- The study looked at if breast-conserving therapy (BCT) is a safe treatment for women with multiple spots of breast cancer.
- They found that the treatment resulted in a low chance (3.1%) of the cancer coming back after five years for most patients who participated in the trial.
- It was noted that women who had a pre-surgery MRI had a much lower chance of cancer returning, suggesting that using MRI before surgery can be very helpful.