Publications by authors named "H Syme"
Feline hyperthyroidism (FHT) is a debilitating disease affecting > 10% of elderly cats. It is generally characterised by chronic elevation of thyroid hormone in the absence of circulating TSH. Understanding of the molecular pathogenesis of FHT is currently limited.
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- - Primary aldosteronism (PA) is a major cause of high blood pressure in humans, often linked to specific gene mutations in adrenal tumors, and studying these mutations in cats may provide insights into adrenal gland function and PA.
- - In a study of 13 cats with aldosterone-secreting tumors, researchers used advanced DNA and RNA sequencing techniques to identify mutations that likely affect protein function and contribute to aldosterone secretion.
- - The study found mutations in genes common to both cats and humans with PA, suggesting shared evolutionary pressures leading to increased aldosterone secretion, despite differences in gene expression levels between the two species.
Background: Functionality of human adrenal tumors is inferred by CYP11B1 (cortisol synthase) expression, CYP11B2 (aldosterone synthase) expression, or both.
Hypothesis/objectives: Nonfunctional canine adrenal tumors have low expression of steroidogenic enzymes, whereas aldosterone-producing tumors express CYP11B, and cortisol-producing tumors express both CYP11B and CYP17.
Animals: Twenty-two client-owned dogs with adrenocortical tumors (ACT) (8 nonfunctional, 7-cortisol producing, 2 aldosterone-producing and 5 functional noncortisol producing) and 2 dogs with normal adrenal glands.
Background: Knowledge of additional risk factors for thrombotic disease (TD) among dogs with renal proteinuria is limited; these might differ for TD affecting the systemic arterial (AT), systemic venous (VT), and pulmonary circulation (PT).
Hypothesis/objectives: To compare signalment and clinicopathological data between dogs with renal proteinuria with or without TD, and between dogs with AT, VT, and PT.
Animals: One hundred fifty client-owned dogs with renal proteinuria, 50 of which had TD.
Background: GS-441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. However, the use of its prodrug, remdesivir, in combination with a PO GS-441524 containing product for the treatment of FIP has not yet been described.
Objectives: Describe treatment protocols, response to treatment and outcomes in cats with FIP treated with a combination of PO GS-441524 and injectable remdesivir.