Using Otoliths to Understand Historic and Contemporary Selenium Exposure in Kokanee Salmon (Oncorhynchus nerka) in Kluane National Park and Reserve, Yukon Territory.

The Kokanee salmon population in Kluane National Park and Reserve (Yukon Territory) declined significantly between 2002 and 2012. Elevated levels of selenium (Se), which can affect fish reproduction, were recently measured in waters used by spawning Kokanee. To investigate whether Se may be contributing to long-term population declines, and in the absence of long-term data on aqueous Se concentrations, Se concentrations in sagittal otoliths - fish ear-bones that chronicle lifetime exposure - were measured and compared in Kokanee sampled in 1981 (a year with many spawners) and 2019-2021.

Factors and mechanisms driving among-lake variability of mercury concentrations in a benthivorous fish in the canadian subarctic.

Wild-caught fish are an important subsistence food source in remote northern regions, but they can also be a source of exposure to mercury (Hg), which has known health hazards. We investigated factors and mechanisms that control variability of Hg concentrations in Lake Whitefish (Coregonus clupeaformis) among remote subarctic lakes in Northwest Territories, Canada. Integrating variables that reflect fish ecology, in-lake conditions, and catchment attributes, we aimed to not only determine factors that best explain among-lake variability of fish Hg, but also to provide a whole-ecosystem understanding of interactions that drive among-lake variability of fish Hg.

Harvester selection and observed mercury levels in Eastern Beaufort Sea and Western Hudson Bay beluga whales (Delphinapterus leucas).

Mercury in marine biota has been extensively studied across Inuit Nunaat because it bioaccumulates and biomagnifies in high trophic level species, such as the beluga whale (Delphinapterus leucas), or qilalugaq in Inuktut. Qilalugaait (pl) are a staple in many coastal Inuit communities, including Tuktoyaktuk, Northwest Territories and Arviat, Nunavut. We examine how total mercury (THg) concentrations in two beluga populations are influenced by biased sampling resulting from local harvester preferences.

Blinatumomab infusion interruptions in pediatric patients rarely lead to readmission.

Blinatumomab is a bispecific T-cell engager administered as a 28-day continuous infusion. Infusions can be associated with interruptions requiring support from clinical staff, but the frequency of interventions with outpatient blinatumomab has not been characterized. This study is a single-center, retrospective review of patients who received blinatumomab between December 3, 2014 and October 31, 2021 to determine frequency and type of interventions.

The mathematical word problem-solving performance gap between children with and without math difficulties: does working memory mediate and/or moderate treatment effects?

This study determined the extent to which working memory (WM) played a moderating and/or mediating role in word-problem-solving (WPS) instructional outcomes between children with and without math difficulties (MD). A randomized pretest-posttest control group study investigated the effects of 8-week strategy instruction in one of four treatment conditions on WPS accuracy of third graders with MD ( = 136) when compared to children with ( = 28) and without MD ( = 43). Comparisons were made of three strategy conditions that included overt cues (e.