Homozygous factor V Leiden and double heterozygosity for factor V Leiden and prothrombin mutation.

The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM). Homozygous FVL and PTM have long been feared conditions thought to cause high rates of morbidity and mortality. To analyse clinical features in patients with homozygous FVL and PTM, as well as patients with double heterozygosity for FVL and PTM.

Abnormal uterine artery Doppler in pregnancies suspected of a SGA fetus is related to increased risk of recurrence during next pregnancy.

Objective: To investigate if placental Doppler velocimetry can predict the recurrence of a small-for-gestational age (SGA) fetus in subsequent pregnancies.

Design: Retrospective study.

Setting: City cohort over 15 years attending a university hospital.

Gm phenotype linkage to subsets of juvenile chronic arthritis (JCA) with influence on IgG subclass response.

The serum hyper IgG of 76 JCA patients of different clinical subsets, 8 systemic, 37 polyarticular and 31 oligoarticular, were investigated by IgG subclass quantitation and Gm allotype determination. The well known increased serum IgG in JCA was confirmed as increased IgG1, IgG2 and IgG3 in the whole group. Investigating the clinical subsets IgG1 was significantly increased in all subsets while IgG2 and IgG3 increased only in the polyarticular form.

Treatment of growth failure with human growth hormone in patients with juvenile chronic arthritis. A pilot study.

Six children with JCA and one with SLE, aged 11.7 to 17.1 years, have been treated with human growth hormone (hGH) for six months to three years because of growth retardation.

Occurrence of autoantibodies against neutrophil granulocyte components in juvenile chronic arthritis.

This study included 96 patients with juvenile chronic arthritis of whom 47% had antinuclear antibodies (ANA). The highest frequency (58%) was seen in the oligoarticular subset, followed by the polyarticular and systemic subsets with ANA in 42% and 17% of the patients, respectively. Sixteen patients (17%) of whom 13 belonged to the polyarticular subset had granulocyte specific ANA (GS-ANA) with a titre greater than or equal to 1/50.