A comparative study of five centrally acting drugs on the pharmacological treatment of obesity.

Context: No long-term studies have compared centrally acting drugs for treating obesity.

Objective: To compare the efficacy and safety of diethylpropion (DEP), fenproporex (FEN), mazindol (MZD), fluoxetine (FXT) and sibutramine (SIB) in promoting weight loss.

Design And Setting: A prospective, randomized, placebo (PCB)-controlled study conducted at a single academic institution.

Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome.

Objective: To evaluate the associations between leptinemia and the components of metabolic syndrome (MetS).

Methods: Fifty-one obese adults (9 men; 36.7 +/- 10.

Infeccions as the etiology for obesity.

The role of infection on obesity development has been questioned since the early 1980's. Several studies on animals have shown that physiopathologic mechanisms through which infections can produce obesity do exist. At least eight types of obesity-inducing viruses have been identified in animals, especially poultry and mice.

[Brazilian Consensus on second-generation antipsychotics and metabolic disorders].

Objective: To discuss current aspects of use of antipsychotics considering their metabolic side effects profile, which includes weight gain, dyslipidemias, diabetes and metabolic syndrome. Such metabolic effects increase the risk of mortality by cardiovascular disease, which is the leading cause of death among schizophrenic patients.

Method: A consensus meeting was held, with participation of endocrinologists and psychiatrists specialists in schizophrenia and, based on a literature review, an article was elaborated emphasizing practical and helpful recommendations to clinicians.