Measurements of tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots of people receiving pre-exposure prophylaxis for HIV with co-formulated tenofovir disoproxil fumarate and emtricitabine.

Background/purpose(s): Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in the Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) (TDF/FTC) are limited, and the associations between the frequency of TDF/FTC administration and drug concentration among people receiving on-demand PrEP remain unclear.

Methods: Fifty-seven participants receiving daily TDF/FTC and 113 participants receiving on-demand TDF/FTC were enrolled in this study. The concentrations of TFV-DP and FTC-TP were measured in dried blood spots using liquid chromatography‒mass spectrometry.

Type I interferon protects against bone loss in periodontitis by mitigating an interleukin (IL)-17-neutrophil axis.

Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation.

Sinomenine synergistically enhances 5-Fu anticancer effects in oral cancer through modulating the miR-140-5p-PDK1-anaerobic glycolysis pathway.

Oral squamous cell carcinoma (OSCC) is a type of human malignancy with a high mortality rate worldwide. Sinomenine (SIN), an active component of sinomenium acutum, has shown potential antitumor activities in various types of cancers. This study discovered that the combination of 5-Fu and SIN treatments had synergistic inhibitory effects on OSCC cells (CI<1).

Post-Modification of MOF with Electron Donor for Efficient Photocatalytic Oxidative Organic Transformations.

Construction of donor-accepter systems via self-assembling electron donor and acceptor chromophores within one single metal-organic framework (MOF) for advanced artificial photosynthesis is of great intertest yet a major challenge. Herein, an electron donor porphyrin 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (PCOOH) was successfully integrated into a highly stable and porous electron acceptor naphthalene diimide (NDI)-based MOF (Zr-NDI) through the post-modified approach of solvent-assisted ligand incorporation (SALI). Benefiting from the efficient photoinduced electron transfer (PET) from the donor PCOOH anchored on the Zr-nodes to the acceptor NDI ligand, which contributes to the abundant generation of reactive oxygen species (ROS) of superoxide radical (O2·-), the resulting MOF Zr-NDI-PCOOH exhibited superior photocatalytic activities that among the highest levels of MOF-based photocatalysts to aerobic oxidation reactions, including hydroxylation of arylboronic acids and homocoupling of amines.

Identification of genetic factors underlying severe retinopathy of prematurity in preterm infants.

Objective: Retinopathy of prematurity (ROP) is a pathological condition characterized by abnormal proliferation of retinal vessels and it represents the primary cause of visual impairment in preterm infants. There is increasing backing for the involvement of genetic factors in the onset of ROP.

Methods: A prospective cohort study assessed the allele frequency and genotype distribution of gene polymorphisms in angiogenesis, inflammation and oxygen-sensing pathways in preterm infants with severe ROP.