Publications by authors named "H Sumida"

Article Synopsis
  • * The study included 230 SSc patients and trained a convolutional neural network to identify PH, achieving an AUC of 0.826, which is slightly better than cardiologists' assessments (0.804).
  • * The deep learning model not only effectively detected PH but also showed a promising prognosis with a 5-year survival rate of around 83-85% for patients diagnosed with PH, indicating its potential clinical utility.
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Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non-taste perception and tissue-specific functions. Keratinocytes that express TAS2Rs in the skin provide a first-line defense against external threats.

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Article Synopsis
  • Previous studies have noted the mutational landscape of extramammary Paget's disease (EMPD), but the impact of genetic alterations on prognosis, especially CDKN2A loss, was not previously explored.* -
  • In a retrospective study involving 167 registered EMPD cases, researchers found that CDKN2A loss was the most common variant, and both CDKN2A and BRCA2 mutations were linked to worse patient outcomes.* -
  • Patients with CDKN2A mutations had a significantly poorer prognosis compared to those without, and those with BRCA2 mutations also fared worse, indicating the importance of genetic profiling in understanding EMPD prognosis.*
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Selective immunoglobulin M (IgM) deficiency (sIgMD) is a rare immunodeficiency disorder characterized by decreased serum levels of IgM. Symptoms of sIgMD include repeated infections and allergic manifestations such as asthma and allergic rhinitis. The etiology and pathology of sIgMD remain largely unknown.

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Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses.

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