Publications by authors named "H Sugimura"
STIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. However, its role in non-small-cell lung carcinoma (NSCLC) remains unclear. In this study, we examined STIL expression and its potential association with chromosomal numerical abnormalities (CNAs) in NSCLC using The Cancer Genome Atlas (TCGA) dataset, immunohistochemical analysis, and in vitro experiments with NSCLC cell lines designed to overexpress STIL.
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- * In a cohort of 51 CRC patients from Rwanda, TP53 variants were found in 45.1% of cases, primarily of the missense type, with notable mutations including c.455dup, c.524G>A, and c.733G>A, and a predominance of specific mutation sequences.
- * The study also revealed that most TP53 mutations were associated with the CMS2 subtype, suggesting that these variants may play a significant role in the development of this
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- The study explores how dietary habits may influence the prevention and management of schizophrenia (SCZ) and bipolar disorder (BD) in older adults, particularly in relation to genetic predispositions and lifestyle-related diseases.
- A cohort of 730 older patients was assessed for their dietary habits across various food categories while calculating polygenic risk scores (PRSs) for SCZ and BD based on large-scale genetic studies.
- Findings indicated that higher genetic risk for SCZ and BD is correlated with lower consumption of nutrient-rich foods like light-colored vegetables and soybeans, with notable differences in dietary impacts between types of BD, especially BD I.
When in contact with charged solid surfaces, ionic liquids (ILs) are known to form solvation structures consisting of alternating cation and anion layers. This phenomenon is considered to originate from the adsorption layer of counterions overcompensating the surface charge, so-called overscreening. However, the response of these layers to surfaces with near-zero or extremely high surface charge density (σ) remains inadequately understood.
View Article and Find Full Text PDFThe synthesis of a spirolactone analogue of xylapyrraside B, a potent antioxidant agent, is described. The key step is the stereoselective formation of the spirolactone skeleton via the formal [3+2] annulation of the isopropylidene-protected glyceraldehyde and δ-methylene lactone, mediated by trifluoroborane etherate. This study addresses the stereoselective synthesis of pyrrolomorpholine spiroketal alkaloids, enabling the production of these bioactive compounds and their analogues.
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