Haematopoietic transplant potential of unrelated and related cord blood: the first six years of the EUROCORD/NETCORD Bank Germany.

To date, human umbilical cord blood (CB) has been employed successfully in well over 1000 allogeneic (unrelated and sibling) stem cell transplantations. Because of primary limitations in volume and cell numbers, over 90% of these transplantations were performed in children. Therefore requests for well standardised cord blood units of high quality are now increasing constantly.

Hb Kurdistan [alpha 47(CE5)Asp-->Tyr], a new alpha chain variant in combination with beta (0)-thalassemia.

We have characterized the structural abnormality of a new alpha chain mutant found in a Kurdish family. The clinical and hematological investigation of eight individuals have shown that the alpha variant is associated with a beta(0)-thalassemia mutation (nonsense codon 39). The tryptic peptide map and sequencing of the abnormal peptide revealed the substitution of an aspartic acid by a tyrosine residue at position 47 of the alpha chain; furthermore, selective amplification and molecular analysis of both alpha genes have assigned the new mutation to the alpha 2 gene.

[Bilateral lymphoblastic lymphoma of the breast].

A 21-year-old female patient presenting with bilateral lymphoblastic lymphoma of the breast was given two four-week courses of cytostatic therapy using the ALL/AUL protocol. Radiation therapy was used as an adjunct. Treatment resulted in tumour regression.

[Results of the operative treatment of stress incontinence in women with urethro-vesical suspension according to Pereyra (author's transl)].

From 1971-1979, 380 women with marked stress incontinence had urethro-vesical suspensions according to Pereyra. In the majority of the cases this urethrovesical suspension was done as an additional operation to vaginal hysterectomy and anterior and posterior colporrhaphy. The follow-up examination of 189 patients 6 to 60 months after the operation included as for the pre-operative examination the history, the gynaecological findings, the Bonney test, the residual urine determination, chromocystoscopy, urinalysis with culture and sensitivity and a lateral cysto-urethrogram.