Publications by authors named "H Stephen"
The Future of Electro-organic Synthesis in Drug Discovery and Early Development.
ACS Org Inorg Au
December 2024
Electro-organic chemistry presents a promising frontier in drug discovery and early development, facilitating novel reactivity aligned with green chemistry principles. Despite this, electrochemistry is not widely used as a synthesis and manufacturing tool in drug discovery or development. This overview seeks to identify key areas that require additional research to make synthetic electrochemistry more accessible to chemists in drug discovery and early development and provide potential solutions.
View Article and Find Full Text PDFThe increase in tobacco and alcohol prevalence among Nigerian teenagers necessitates the need to understand the factors influencing use. The aim of this systematic literature review was to synthesis evidence from studies on tobacco and alcohol use among Nigerian adolescents and young adults in order to determine factors influencing tobacco and alcohol use. Six databases MEDLINE, Embase, CINAHL, PsycINFO, PubMed, ScienceDirect, and Google Scholar were used to search for peer-reviewed articles reporting the prevalence and predictors of tobacco and alcohol use among adolescents/youths published between 2010 and 2022.
View Article and Find Full Text PDFArticle Synopsis
- Large-scale assessments of soil-transmitted helminth (STH) programs are critical for understanding the need for mass drug administration (MDA) in India; baseline surveys showed high prevalence rates of STHs in Chhattisgarh (80.2% in 2015) and Himachal Pradesh (29.0% in 2016).
- Follow-up surveys in 2018 revealed a dramatic drop in prevalence after multiple rounds of MDA, with Chhattisgarh showing an 85.5% reduction to 11.6% and Himachal Pradesh achieving a remarkable 99.0% reduction to 0.3%.
- The significant decrease in STH infections is attributed to the effectiveness of sustained de
EFSA was asked for a scientific opinion on the risks to public health related to the presence of -nitrosamines (-NAs) in food. The risk assessment was confined to those 10 carcinogenic -NAs occurring in food (TCNAs), i.e.
View Article and Find Full Text PDFBackground: This study was conducted to investigate the cascade involving DNA damage, senescence, and senescence-associated secretory phenotype (SASP) in experimental diabetes and in a four-year follow-up study in patients with pre-diabetes and type 2 diabetes.
Methods: Kidney, lung, and liver were studied in 4 months diabetic db/db mice and age-matched controls for the presence of DNA damage and fibrosis. DNA damage (comet-tail-length and ɤH2Ax-positivity in white blood cells), urinary p21-excretion, and plasma IL-6 and TGF-β1 were determined from 115 healthy participants, 34 patients with pre-diabetes and 221 with type 2 diabetes.