Publications by authors named "H Stassen"
Genetic determinants of antidepressant and antipsychotic drug response.
Eur Arch Psychiatry Clin Neurosci
October 2024
Article Synopsis
- * A study with 902 patients investigated the effectiveness of these treatments, using genetic analysis of 100 candidate genes to assess recovery patterns and side effects over time.
- * The researchers developed a new method using neural networks to identify genetic patterns associated with treatment responses, achieving high classification accuracy for both responder and non-responder patients.
: Traumatic spinal injury in children is a rare but serious life event. Predicting pediatric patients at risk for spinal injury remains difficult. This study focuses on the cause of the injury and predictors to identify children at risk and appropriate diagnostic procedures.
View Article and Find Full Text PDFEpidemiologic data indicate that overweight and obesity are on the rise worldwide. Psychiatric patients are particularly vulnerable in this respect as they have an increased prevalence of overweight and obesity, and often experience rapid, highly undesirable weight gain under psychotropic drug treatment. Current treatment strategies in psychiatry are oriented towards polypharmacy, so that the information on drug-induced weight gain from earlier monotherapy studies is of very limited validity.
View Article and Find Full Text PDFBackground: This study analyzed the extent to which irregularities in genetic diversity separate psychiatric patients from healthy controls.
Methods: Genetic diversity was quantified through multidimensional "gene vectors" assembled from 4 to 8 polymorphic SNPs located within each of 100 candidate genes. The number of different genotypic patterns observed per gene was called the gene's "diversity index".
Background: The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting of weight gain associated with lithium and other mood stabilizers compared to lamotrigine which is considered free of metabolic adverse drug reactions (ADRs).
Methods: We conducted a case/non-case pharmacovigilance study using data from the AMSP project (German: "Arzneimittelsicherheit in der Psychiatrie"; i.