Publications by authors named "H Staiger"
Abstract: Metastable levels of highly charged ions that can only decay via highly forbidden transitions can have a significant effect on the properties of high temperature plasmas. For example, the highly forbidden 3d - 3d 4 s magnetic octupole (M3) transition in nickel-like ions can result in a large metastable population of its upper level which can then be ionized by electrons of energies below the ground state ionization potential. We present a method to study metastable electronic states in highly charged ions that decay by x-ray emission in electron beam ion traps (EBIT).
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- Lichen sclerosus (LS) is a poorly understood inflammatory condition primarily affecting the genital areas, mostly in postmenopausal women, but also seen in men and children; its causes are still unclear despite links to hormonal changes and autoimmune issues.
- The disease is characterized by chronic whitish patches, itching, and potential complications like genital scarring, sexual dysfunction, and an increased risk of squamous cell carcinoma; diagnosis is mostly clinical with skin biopsies performed as needed.
- Treatment typically involves potent topical corticosteroids, with some emerging alternatives like topical calcineurin inhibitors, but overall, LS has limited treatment options and requires further research to better understand its features and management.
The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.
View Article and Find Full Text PDFObjective: Elevated plasma glutamate levels are associated with an increased risk of cardiovascular disease (CVD). Because plasma glutamate levels are also strongly associated with visceral adiposity, nonalcoholic fatty liver disease, insulin resistance, and high circulating levels of branched-chain amino acids (BCAAs), it is unknown to what extent elevated circulating glutamate is an independent marker of an increased risk of atherosclerosis.
Methods: Plasma levels of glutamate and BCAAs were measured in 102 individuals who were precisely phenotyped for body fat mass and distribution (magnetic resonance [MR] tomography), liver fat content (1H-MR spectroscopy), insulin sensitivity (oral glucose tolerance test and hyperinsulinemic, euglycemic clamp [N = 57]), and carotid intima media thickness (cIMT).