Publications by authors named "H Sridhar"
Article Synopsis
- - The study investigates how postpartum depression and anxiety affect mothers' caregiving and their perceived distress, especially in low-and-middle-income countries where informal support is crucial due to limited healthcare access.
- - Interviews with six mothers reveal four key themes: uncertainty and helplessness, misattunement with family, personal strength from family support, and alternative coping strategies.
- - The findings emphasize that while family support is essential for recovery, it must be properly aligned with mothers' needs; otherwise, it can contribute to additional distress.
Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we performed detailed clinicopathologic, genomic, and transcriptomic profiling of an atypical subset of SCLC that lacked RB1 and TP53 co-inactivation and arose in never/light smokers. We found that most cases were associated with chromothripsis-massive, localized chromosome shattering-recurrently involving chromosome 11 or 12 and resulting in extrachromosomal amplification of CCND1 or co-amplification of CCND2/CDK4/MDM2, respectively.
View Article and Find Full Text PDFIntroduction: Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence supports plasticity among subtypes with a bias toward adoption of low-NE states during disease progression or upon acquired chemotherapy resistance. Here, we identify a role for SMARCA4, the catalytic subunit of the SWI/SNF complex, as a regulator of subtype shift in SCLC.
View Article and Find Full Text PDFArticle Synopsis
- * Identifying high-risk patients is possible through TP53 and RB1 mutations, but there are currently no strategies to prevent this transformation.
- * Targeting the CDC7 kinase with the inhibitor simurosertib may block NE transformation and improve responses to both targeted and standard chemotherapy in experimental models, indicating a potential new treatment approach for these cancers.