Publications by authors named "H Sperling"
Article Synopsis
- Testosterone replacement therapy is a primary treatment for low testosterone levels and requires understanding its timing and methods.
- Potential side effects include impacts on bones, heart health, sexual function, development of gynecomastia (breast tissue in men), fertility issues, and contraception concerns.
- Caution is advised due to possible links between testosterone therapy and prostate cancer.
Molecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and expedite discovery. Here we unveil a trans-labeling covalent molecular glue mechanism, termed 'template-assisted covalent modification'.
View Article and Find Full Text PDF