Publications by authors named "H Solak"
Depression is responsible for neuropathies such as decreased neurogenesis and increased dendritic atrophy. There is information that antidepressant treatments have an effect by increasing hippocampal neurogenesis and neurotrophic factor expression. The neuropeptide Y1 (NPY1R) receptor agonist has been suggested to have anxiolytic effects.
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- - The study examined how altitude affects the gut microbiome of Anatolian Blind Mole Rats using 16S rRNA metabarcoding, noting significant changes in bacterial composition based on elevation, particularly with facultatively anaerobic bacteria being more abundant at higher altitudes.
- - Microbiome alpha diversity was highest at mid-altitude, showing a mix of low and high elevation elements, while beta diversity was notably influenced by altitude; however, diet composition varied with altitude without affecting its diversity.
- - There was no clear genetic structure related to altitude among the host populations, and while free thyroxine levels increased with altitude, no specific bacteria correlated with hormone levels, although total thyroxine showed a positive connection to microbiome diversity.
Elevated levels of oxLDL and LOX-1: Implications for schizophrenia pathophysiology.
J Psychiatr Res
September 2024
Inflammation and oxidative stress are both considered to be factors in the etiopathogenesis of schizophrenia. LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) and ox-LDL (oxidized low-density lipoprotein) have been reported to be active in neuroinflammation pathways in which they are involved in oxidative stress and inflammation. However, its relationship with schizophrenia is unclear.
View Article and Find Full Text PDFAlzheimer's disease (AD) is an age-related neurodegenerative disorder characterised by cognitive dysfunction, memory loss and mood changes. Hippocampal neurogenesis has been suggested to play a role in learning and memory. Neurokinin 3 receptor (NK3R) has been shown to be prevalent in the hippocampus region.
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- Alzheimer's disease (AD) is characterized by progressive dementia and affects cholinergic systems, with neurokinin 3 receptor (NK3R) playing a role in memory and learning.
- A study was conducted using 50 male Wistar albino rats that were divided into various groups, including AD and NK3R agonist-treated groups, to assess the behavioral and neurotransmitter changes after administering the NK3R agonist senktide.
- Results showed that while the AD group struggled with learning in the Morris water maze (MWM) test, the NK3R agonist improved cognitive functions and learning potential in the AD model, likely through cholinergic mechanisms.