Publications by authors named "H Soh"
Article Synopsis
- Variants associated with neurodevelopmental impairments in children are complex and challenging to evaluate due to their diverse nature and unclear causes.
- The study highlights a case of a child with neonatal-onset epilepsy and a specific genetic variant (G256W) that impacts ion channel function and leads to reduced cell stability and conduction in nervous tissue.
- The research also establishes a mouse model that exhibits epilepsy and hyperexcitability in brain cells, linking the genetic variant to observable neurological behaviors and suggesting potential wider implications for understanding similar conditions in other patients.
Background: In middle-income countries, healthcare systems face unique challenges in ensuring timely antenatal detection of congenital abnormalities that require pediatric surgical intervention. Early detection can significantly improve outcomes, yet resource constraints often limit access to diagnostic technologies. This study evaluates the antenatal detection rate of congenital abnormalities referred to pediatric surgical services in three Malaysian tertiary centers and examines its effect on maternal anxiety.
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- A model was developed to analyze the noise and randomness in fluorescence signals under continuous wave (CW) and time-gated (TG) conditions, focusing on how different excitation photon flux affects fluorophore emission.
- Both ensemble and stochastic models were validated through Monte Carlo molecular dynamics simulations using the Gillespie algorithm, showing their effectiveness in capturing the dynamics of fluorescence.
- The study explores the implications of the model for designing biomolecular fluorescence detection systems, emphasizing trade-offs related to signal-to-noise ratios and detection limits as systems shrink to micro- and nano-scales, highlighting the advantages of TG systems in terms of cost and complexity when suitable fluorophores are used.
Purpose: This study aimed to investigate the current practices in the diagnosis and surgical management of anorectal malformations (ARMs) in female patients in Japan, specifically focusing on anovestibular fistula (AVF), rectovaginal fistula (RVF), and persistent cloaca (PC).
Methods: An anonymous online survey was conducted with 61 institutional members of the Japanese Study Group for Anorectal Anomalies.
Results: Sixty-one institutions (100%) completed the survey.
Outcome Evaluation of Three-Dimensionally Printed Patient-Specific Surgical Plates for Mandibular Reconstruction.
Craniomaxillofac Trauma Reconstr
August 2024
Article Synopsis
- The study evaluated the effectiveness and accuracy of 3D-printed surgical plates for reconstructing mandibular defects compared to traditional plates, involving both prospective and retrospective research designs.
- A total of 20 patients (10 in each group) who received vascularized bone grafts were assessed for flap survival, complications, and facial appearance post-surgery.
- Results showed that while overall outcomes were similar, 3D-printed plates improved the position and shape of the lower mandibular border, highlighting their safe and effective application in individualized mandibular reconstruction.