Publications by authors named "H Skinner"
Background: For patients with head and neck squamous cell carcinoma (HNSCC), failure of definitive radiation combined with cisplatin nearly universally results in death. Although hyperactivation of the Nrf2 pathway can drive radiation and cisplatin resistance along with suppressed anti-tumor immunity, treatment-refractory HNSCC tumors may retain sensitivity to targeted agents secondary to synergistic lethality with other oncogenic drivers (e.g.
View Article and Find Full Text PDFObjective: Behavioral or conduct problems (BCPs) are common co-occurring conditions in children with special health care needs (CSHCNs), affecting their developmental and functional milestones. The role of family resilience in mitigating BCPs among these children and how adverse childhood experiences (ACEs) affect this dynamic remain largely unclear. The aim of the study was to disentangle the complex interplay between family resilience, ACEs, and BCPs by examining how ACEs moderate the relationship between family resilience and BCPs.
View Article and Find Full Text PDFArticle Synopsis
- Recent findings highlight the importance of communication between lysosomes and mitochondria in regulating tumor growth, particularly in squamous cell carcinomas (SCCHN) with high TMEM16A expression.
- About 30% of SCCHN cases overexpress TMEM16A, leading to increased mitochondrial content and reliance on mitochondrial complex I for cancer cell survival.
- Targeting the interaction between lysosomal and mitochondrial functions may offer new therapeutic strategies for improving outcomes in patients with SCCHN.
An Evaluation of Primary Care Clinician Referrals for Behavioral Weight Loss Counseling.
J Prim Care Community Health
December 2024
Introduction/objectives: In the context of enrolling patients from primary care practices into a weight loss research study, this study describes the percentage of patients primary care clinicians (PCCs) considered appropriate for referral and study participation rates among those referred.
Methods: An electronic health record review identified 5322 patients aged 18 to 75 years with BMI ≥ 30 kg/m as eligible for review by community, attending, and resident PCCs for referral to a weight loss study. Referrals and patient interest in participating in the study are reported overall and by PCC type.
Article Synopsis
- Cancer is predicted to rise significantly, with 35 million new cases expected by 2050, mainly impacting low- and middle-income countries, particularly in the SAARC region.
- There is a research investment and output gap in SAARC countries compared to high-income nations, leaving a lack of local studies and clinical trials in crucial areas like targeted therapy and immunotherapy.
- Addressing the challenges of healthcare access, cultural and economic barriers, and limited funding in SAARC countries requires collaboration, improved research infrastructure, and local studies to develop practical and affordable cancer treatments.