Publications by authors named "H Shichi"
Article Synopsis
- Corticotroph tumors, specifically ACTHomas, could be potential targets for immunotherapy due to their susceptibility to immune cell attack, particularly in conditions like hypophysitis.
- The study analyzed tumor-infiltrating immune cells in different cortisol environments and found that ACTHomas had low levels of CD8+ T cells compared to other pituitary tumors, suggesting they may be "immunologically cold."
- It was observed that CD4+ T cells and certain macrophages were more abundant in cortisol-exposed tumors, indicating a relationship between cortisol levels and immune response, thus highlighting the need for further research on effective immunotherapy approaches.
Purpose: Predicting the therapeutic effects of first-generation somatostatin receptor ligands (fg-SRLs) is important when assessing or planning effective treatment strategies in patients with acromegaly. The oft-used maximum growth hormone (GH) suppression rate parameter of the octreotide test has a suboptimal predictive value. Therefore, this study explored newer parameters of the octreotide test for predicting the therapeutic effect of long-acting fg-SRLs.
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- Multiple endocrinopathies, particularly the rare combination of hypophysitis and type 1 diabetes mellitus (T1DM), can occur as adverse events from immune checkpoint inhibitors (ICIs) like anti-PD-1 antibodies.
- In a study analyzing three cases along with existing reports, it was found that all patients had specific human leukocyte antigen (HLA) haplotypes linked to hypophysitis, and these cases predominantly affected men in their 60s.
- The onset of endocrine disorders occurred similarly in both combined and single endocrinopathy cases, indicating no significant difference in the time frame from ICI treatment initiation to disease manifestation, suggesting the need for more research on this condition.
Kenny-Caffey syndrome type 2 (KCS2) is an extremely rare skeletal disorder involving hypoparathyroidism and short stature. It has an autosomal dominant pattern of inheritance and is caused by variants in the FAM111 trypsin-like peptidase A () gene. This disease is often difficult to diagnose due to a wide range of more common diseases manifesting hypoparathyroidism and short stature.
View Article and Find Full Text PDFThere is uncertainty regarding the need for COVID-19 peri-vaccination glucocorticoid coverage in patients with adrenal insufficiency. In this survey conducted in a single tertiary medical institution, 167 consecutive outpatients taking physiological glucocorticoids because of adrenal insufficiency were included. The patients declared if they developed an adrenal crisis after vaccination, and the amount and duration of an increase in their glucocorticoid dosage, if any.
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