Publications by authors named "H Shibayama"
Article Synopsis
- This study is a follow-up on the effectiveness and safety of tazemetostat for Japanese patients with relapsed/refractory follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) who have the EZH2 mutation, after a median follow-up of 35 months.
- The FL cohort had an impressive objective response rate of 70.6%, with significant progression-free survival (PFS) rates at 24 and 36 months (72.1% and 64.1% respectively), while no unexpected severe adverse events were reported.
- Overall, long-term treatment with tazemetostat appears to be a promising and safe option as a third-line or later therapy for patients with this specific
The prognosis for multiple myeloma (MM) patients has improved with the advent of new drugs, but the prognosis with renal impairment (RI) is poor. The choice of treatment in such cases is critical, but there are no set criteria. We examined the impact of RI on initial therapy in transplant-ineligible MM patients.
View Article and Find Full Text PDFBackground: Isatuximab, an anti-CD38 antibody, has been widely used in treatments for patients with relapsed/refractory multiple myeloma (MM). Despite its high efficacy, not all patients achieve a lasting therapeutic response with isatuximab.
Objective: We tried to identify biomarkers to predict the effectiveness of isatuximab by focusing on the host's immune status before treatment.
The emergence of novel drugs has significantly improved outcomes of patients with plasma cell neoplasms (PCN). The Japanese Society of Hematology conducted a prospective observational study in newly diagnosed PCN patients between 2016 and 2021. The analysis focused on 1385 patients diagnosed with symptomatic PCN between 2016 and 2018.
View Article and Find Full Text PDFResponse determined by 18[F]-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography (PET)-CT after induction therapy can predict progression-free survival (PFS) in follicular lymphoma (FL). However, little prospective research has examined the significance of PET after second-line therapy. We conducted a prospective multicenter phase II trial (W-JHS NHL01) of bendamustine plus rituximab (BR) without rituximab maintenance for FL in first relapse.
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