Publications by authors named "H Shiang"
The prevalence of FOXP3+ regulatory T-cells in peripheral blood of patients with NSCLC.
Cancer Biother Radiopharm
June 2009
Article Synopsis
- The study examined regulatory T-cells (T(regs)) in patients with non-small-cell lung cancer (NSCLC) compared to healthy donors, finding an increase in specific T(reg) populations in both blood and pleural effusion.
- These T(regs) expressed high levels of CTLA-4 and GITR, and were shown to be nonresponsive to stimulation, effectively suppressing the activity of other T-cells during experiments.
- The findings suggest that the elevated T(reg) levels may hinder the immune system's ability to fight NSCLC, indicating their potential importance in developing immunotherapy strategies.
There is concern regarding the interaction of magnesium sulfate and nifedipine used concomitantly in obstetrical patients, because both are calcium channel antagonists and may induce myocardial depression as well as peripheral vasodilatation. The objective of this study was to determine the hemodynamic consequences of concomitant administration of nifedipine and magnesium sulfate in anesthetized pigs. Twelve pigs were anesthetized with sodium pentobarbital, intubated mechanically ventilated.
View Article and Find Full Text PDFImportance of extrasegmental vessels for spinal cord blood supply in a chronic porcine model.
Rev Port Cir Cardiotorac Vasc
April 2016
Unlabelled: IObjective: Our purpose was to investigate the interaction of the important components of spinal cord blood supply in the pig model to enable its use for future studies of spinal cord protection.
Methods: 25 juvenile pigs (20-22 Kg) underwent serial intercostal (IC) or lumbar artery (LA) ligation until disappearance of motor evoked potentials (MEPs). Pigs underwent sequential craniocaudal (IC/LA ligation alone (n=5); following clamping of both subclavian arteries (n=4)m, or clamping of the median sacral artery (MSA, n=4); preceded by clamping of the subclavian arteries (n=4), or of the MSA (n=4).
Changes in regional cerebral blood flow under hypothermic selective cerebral perfusion.
Thorac Cardiovasc Surg
April 2004
Objective: Currently the most frequently used perfusion technique during aortic arch surgery to prevent cerebral damage is hypothermic selective cerebral perfusion (SCP). Changes in cerebral blood flow (CBF) are known to occur during these procedures. We investigated regional changes of CBF under conditions of SCP in a porcine model.
View Article and Find Full Text PDFImportance of extrasegmental vessels for spinal cord blood supply in a chronic porcine model.
Eur J Cardiothorac Surg
November 2003
Objective: Our purpose was to investigate the interaction of the important components of spinal cord blood supply in the pig model to enable its use for future studies of spinal cord protection.
Methods: Twenty-five juvenile pigs (20-22 kg) underwent serial intercostal (IC) or lumbar artery (LA) ligation until disappearance of motor evoked potentials (MEPs). Pigs underwent sequential craniocaudal IC/LA ligation alone (n=5); following clamping of both subclavian arteries (n=4), or clamping of the median sacral artery (MSA, n=4).