Publications by authors named "H Sellak"
Children with beta-thalassemia (BT) present with an increase in carotid intima-medial thickness, an early sign suggestive of premature atherosclerosis. However, it is unknown if there is a direct relationship between BT and atherosclerotic disease. To evaluate this, wild-type (WT, littermates) and BT (Hbb) mice, both male and female, were placed on a 3-mo high-fat diet with low-density lipoprotein receptor suppression via overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation (D377Y).
View Article and Find Full Text PDFThe intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought to determine whether SCD mice exhibit intestinal barrier dysfunction, inflammation, and dysbiosis. Using the Townes humanized sickle cell mouse model, we found a 3-fold increase in intestinal permeability as assessed via FITC-dextran (4 kDa) assay in SS (SCD) mice compared to AA (wild type) mice ( = 4, < 0.
View Article and Find Full Text PDFPrecision health seeks to optimise behavioural interventions by delivering personalised support to those in need, when and where they need it. Conceptualised a decade ago, progress toward this vision of personally relevant and effective population-wide interventions continues to evolve. This scoping review aimed to map the state of precision health behaviour change intervention research.
View Article and Find Full Text PDFArticle Synopsis
- Sickle cell disease (SCD) leads to frequent vascular issues and poor organ performance, with impaired blood flow recovery following vascular injury.
- Research was conducted on SCD mice to see if boosting nitric oxide levels could enhance recovery after induced vascular damage.
- The results showed that treatments like L-Arginine and NO-generating hydrogels did not help recovery and might even worsen the situation by increasing oxidative stress in SCD mice.
Objective: To determine progress and gaps in global precision health research, examining whether precision health studies integrate multiple types of information for health promotion or restoration.
Design: Scoping review.
Data Sources: Searches in Medline (OVID), PsycINFO (OVID), Embase, Scopus, Web of Science and grey literature (Google Scholar) were carried out in June 2020.