Comparison of predicted and actual dermatitis generated from computed tomography images and dose distribution maps.

Anticipating the onset, location and severity of radiation dermatitis before radiotherapy can aid in dermatological care. This study developed a method for creation of a prediction diagram for dermatitis and conducted a comparative verification between the prediction diagram and actual patient condition. The prediction diagram involved converting skin doses into 2 Gy fractionated equivalent doses using α/β of 10.

Successful laparoscopic transabdominal preperitoneal repair of recurrent inguinal hernia of the bladder following bilayer mesh use: A case report.

Introduction: The effectiveness of laparoscopic repair for recurrent inguinal hernias has been previously reported; however, recurrence following bilayer mesh use has rarely been reported. We report a case of successful total laparoscopic repair of a recurrent inguinal hernia of the bladder in which a bilayer mesh was used for the initial direct inguinal hernia.

Presentation Of Case: An 80-year-old man underwent hernia repair using a bilayer mesh for a right direct hernia 12 years ago.

Impact of chronic constipation symptoms on work productivity and daily activity: A large-scale internet survey.

Background And Aim: Chronic constipation negatively impacts work productivity and patients' quality of life. This retrospective study assessed the correlation between symptoms of chronic constipation and work/activity impairment with and without the use of laxative treatment.

Methods: This cross-sectional, observational, web-based survey was conducted using the Work Productivity and Activity Impairment-Chronic Constipation Questionnaire and included Japanese patients with chronic constipation receiving prescribed medication.

Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components.

Some citrus fruits are known to cause clinically significant drug interactions by inhibiting intestinal cytochrome P450 (CYP) enzymes. This in vitro study aimed to investigate the kinetics of the inhibition of CYP3A4 and CYP2C19 by the juice of jabara, a Japanese citrus fruit that does not contain furanocoumarins such as 6',7'-dihydroxybergamottin, and to identify the inhibitory compound(s). CYP3A4 and CYP2C19 activity levels were determined in vitro using recombinant CYP preparations and their respective substrates.

Nomogram Predicting Axillary Lymph Node Dissection Omission After Neoadjuvant Chemotherapy for Node-positive Breast Cancer.

Background/aim: To develop an accurate method to predict nodal pathological complete response (ypN0) in patients after neoadjuvant chemotherapy (NAC) for clinically node-positive breast cancer.

Patients And Methods: We included 128 patients with clinically node-positive primary breast cancer who underwent axillary lymph node dissection after NAC.

Results: Breast primary tumor clinical complete response (ycT0) was observed in 29.