Publications by authors named "H Seitz"
The rubber elasticity theory has been lengthily applied to several polymeric hydrogel substances and upgraded from idealistic models to consider imperfections in the polymer network. The theory relies solely on hyperelastic material models in order to provide a description of the elastic polymer network. While this is also applicable to polymer gels, such hydrogels are rather characterized by their water content and visco-elastic mechanical properties.
View Article and Find Full Text PDFWithin the healthy human body, cells reside within the physiological environment of a tissue compound. Here, they are subject to constant low levels of mechanical stress that can influence the growth and differentiation of the cells. The liposuction of adipose tissue and the subsequent isolation of mesenchymal stem/stromal cells (MSCs), for example, are procedures that induce a high level of mechanical shear stress.
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- Multi-omics data integration is a key focus in toxicology for better understanding cellular responses to chemical exposure; the study reviews current practices and provides guidelines for optimal multi-omics research design.
- Despite recognizing the benefits, the researchers found limited availability of comprehensive multi-omics datasets, hindering a full evaluation of the methodologies used in toxicology.
- In their own study on thyroid toxicity, they utilized a multi-omics approach to identify regulatory responses and discovered that integrating multiple omics layers enhances data interpretation and reveals insights into mechanisms like non-coding RNA involvement.
Background: Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to positively affect residual hearing. To deliver DEX in a localized and controlled way, a round window niche implant (RNI), allowing drug diffusion via the round window membrane into the cochlea, may be used.
View Article and Find Full Text PDFThis review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR.
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