Publications by authors named "H Seethamraju"
Purpose: Early in the course of the SARS-CoV-2 pandemic it was hypothesised that host genetics played a role in the pathophysiology of COVID-19 including a suggestion that the CCR5-Δ32 mutation may be protective in SARS-CoV-2 infection. Leronlimab is an investigational CCR5-specific humanized IgG4 monoclonal antibody currently in development for HIV-1 infection. We aimed to explore the impact of leronlimab on the severity of disease symptoms among participants with mild-to-moderate COVID-19.
View Article and Find Full Text PDFLung transplantation can greatly improve quality of life and extend survival in those with end-stage lung disease. In order to derive the maximal benefit from such a procedure, patients must be carefully selected and be otherwise healthy enough to survive a high-risk surgery and sometimes prolonged immunosuppressive therapy following surgery. Patients therefore must be critically assessed prior to being listed for transplantation with close attention paid towards assessment of cardiovascular health and operative risk.
View Article and Find Full Text PDFProvided advancements in Lung Transplantation (LT) survival, the efficacy of Lung Retransplantation (LRT) has often been debated. Decades of retrospective analyses on thousands of LRT cases provide insight enabling predictive patient criteria for retransplantation. This review used the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) is associated with considerable morbidity and mortality. The number of confirmed cases of infection with SARS-CoV-2, the virus causing COVID-19 continues to escalate with over 70 million confirmed cases and over 1.6 million confirmed deaths.
View Article and Find Full Text PDFArticle Synopsis
- - The COVID-19 pandemic is caused by the SARS-CoV-2 virus, which can lead to severe health issues like pneumonia and multi-organ failure in some patients, though many experience mild or no symptoms at all.
- - This study analyzed DNA methylation patterns in immune cells of critically ill COVID-19 patients and found specific changes like hypermethylation of immune response genes and hypomethylation of inflammatory genes, indicating how the virus manipulates the immune response.
- - The findings suggest that these distinct DNA methylation signatures could help improve clinical assessments and potentially lead to new treatment strategies against severe COVID-19 and its associated mortality risk.