Publications by authors named "H Scott Wilkinson"
Huntington's disease (HD) arises from a CAG expansion in the () gene beyond a critical threshold. A major thrust of current HD therapeutic development is lowering levels of mutant mRNA (m) and protein (mHTT) with the aim of reducing the toxicity of these product(s). Human genetic data also support a key role for somatic instability (SI) in 's CAG repeat - whereby it lengthens with age in specific somatic cell types - as a key driver of age of motor dysfunction onset.
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- - A collaborative effort was made to address the lack of equitable research practices in dance for dementia, aiming to involve those with lived experience in shaping research priorities.
- - Various methods were employed, including in-person and online workshops with a diverse group of participants, such as people living with dementia, health professionals, and researchers.
- - The resulting agenda highlights three key themes: enhancing access to dance, emphasizing co-produced methods, and fostering innovation in research techniques, serving as a foundation for future studies in this area.
Background: There is a pressing need to offer more accessible, evidence-based psychological interventions to secondary school students who are increasingly reporting difficulties with anxiety and low mood. The aim of this pragmatic randomised multiple baseline trial is to evaluate the efficacy of a school-based counselling intervention called Knowledge Insight Tools (KIT) for reducing anxiety and low mood in UK secondary school students. KIT is a flexible intervention delivered individually and informed by cognitive behavioural therapy (CBT).
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- - This study explores how low concentrations of fluoxetine (Prozac), found in polluted water, affect wound healing, highlighting a gap in understanding its impact on humans.
- - The research demonstrated that exposure to fluoxetine accelerated wound closure in human skin cells, showing dose-dependent effects starting from a concentration of 125 ng/l.
- - Mechanistically, fluoxetine enhances wound healing by increasing cell proliferation and altering serotonin signaling, which involves significant changes in gene expression and protein activity linked to cell growth and metabolism.
Antimicrobial resistance (AMR) is one of the greatest threats to human health with a growing body of evidence demonstrating that selection for AMR can occur at environmental antimicrobial concentrations. Understanding the concentrations at which selection for resistance may occur is critical to help inform environmental risk assessments and highlight where mitigation strategies are required. A variety of experimental and data approaches have been used to determine these concentrations.
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