Current Trends in Blood Flow Restriction.

The purpose of the study was to explore how individuals in the United States of America applied BFR/KAATSU devices and administered BFR/KAATSU training. In addition, the study sought to examine safety topics related to BFR/KAATSU training. The study was completed using survey research.

Evaluating Novel Methods of Classifying Interlimb Asymmetries Within Collegiate American Football Players.

Over the last few years, researchers and sport scientists have expressed an increased interest in the effects of interlimb asymmetry on aspects of sport performance such as jumping, sprinting, and changing direction. This study aimed to evaluate the diagnostic utility of three different means of classifying asymmetry to highlight if a 6-week resistance training intervention can meaningfully reduce levels of asymmetry, and to determine the relation between asymmetry reduction and improvements in change of direction (CoD) performance, if any. Eighteen, division-two collegiate American football skill position players completed all pre- and post-intervention procedures.

Determination and control of TEMPO, a potentially genotoxic free radical reagent used in the synthesis of filibuvir.

The synthesis of filibuvir, a hepatitis C virus polymerase inhibitor candidate, involves use of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), a potentially genotoxic free radical reagent. A headspace gas chromatographic method utilizing selected-ion monitoring (SIM) mode mass spectrometric detection was developed, validated and applied to the determination of low levels of TEMPO in filibuvir. The GC-MS method was validated in terms of specificity, linearity, precision, accuracy/recovery, limit of quantitation (LOQ) and limit of detection (LOD).

pH control of nucleophilic/electrophilic oxidation.

Finding formulations that prevent degradation of the active pharmaceutical ingredient is an essential part of drug development. One of the major mechanisms of degradation is oxidation. Oxidative degradation is complex, and can occur via different mechanisms, such as autoxidation, nucleophilic/electrophilic addition, and electron transfer reactions.

Short-term changes in 10-km race pace aerobic demand and gait mechanics following a bout of high-intensity distance running.

Following treadmill accommodation and a 3-day period of tapered running, ten well-trained male distance runners [x maximum oxygen uptake (VO2max) = 71.3 ml.kg-1.