Effect of sodium pentosan polysulphate on the thrombogenicity of prothrombin complex concentrates.

The addition of pentosan polysulphate sodium (NaPPS) to thrombogenic prothrombin complex concentrates (PCC) dose-dependently reduces or abolishes thrombus formation in rats in the stasis model acc. to Wessler. However, no reduction of thrombogenicity was found in PCC preparations manufactured in the presence of NaPPS.

Inhibitory effect of hirudin on thrombosis induced by prothrombin complex concentrates.

The influence of hirudin on thrombus formation induced by prothrombin complex concentrate (PCC) was studied in two different test series in rats. Within the first test series hirudin was i.v.