Computerized measurements of radiographic anatomical parameters of the elbow joint in Bernese Mountain Dogs.

Objective: Comparison of two methods for evaluation of anatomical parameters of elbow joints in Bernese Mountain Dogs.

Study Design: Radiographic analysis.

Animals: Nine hundred and thirty-one radiographs of elbow joints from 305 Bernese Mountain Dogs.

N-methyl pyrrolidone as a potent bone morphogenetic protein enhancer for bone tissue regeneration.

In medicine, N-methyl pyrrolidone (NMP) has a long track record as a constituent in medical devices approved by the Food and Drug Administration and thus can be considered as a safe and biologically inactive small chemical. In the present study, we report on the newly discovered pharmaceutical property of NMP in enhancing bone regeneration in a rabbit calvarial defect model in vivo. At the cellular level, the pharmaceutical effect of NMP was confirmed, in particular, in combination with bone morphogenetic protein (BMP)-2, because NMP increased early and late markers for maturation of preosteoblasts and human bone marrow-derived stem cells in vitro.

Short-term and eight to 12 months results of a tibial tuberosity advancement as treatment of canine cranial cruciate ligament damage.

Objective: To describe the perioperative complications and the six weeks and eight to 12 months outcome of cases of canine cranial cruciate ligament damage treated with a tibial tuberosity advancement.

Methods: The medical records including the six weeks' postoperative re-evaluation and radiographs of dogs with a tibial tuberosity advancement (70 operated stifles) were analysed regarding the short-term outcome and the recorded complications. A questionnaire for the evaluation of the eight to 12 months outcome was sent to the owners and the answers tabulated.

Functionalization of polysulfide nanoparticles and their performance as circulating carriers.

We here present an evaluation of the carrier performance of nanoparticles that are biofunctional, i.e. derivatized to provide a controlled biological activity, and environmentally responsive, since they respond to the presence of oxidants.

Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming.

Bioresorbable scaffolds made of poly(L-lactic acid) (PLA) obtained by supercritical gas foaming were recently described as suitable for tissue engineering, portraying biocompatibility with primary osteoblasts in vitro and interesting mechanical properties when reinforced with ceramics. The behavior of such constructs remained to be evaluated in vivo and therefore the present study was undertaken to compare different PLA/ceramic composite scaffolds obtained by supercritical gas foaming in a critical size defect craniotomy model in Sprague-Dawley rats. The host-tissue reaction to the implants was evaluated semiquantitatively and similar tendencies were noted for all graft substitutes: initially highly reactive but decreasing with time implanted.