Publications by authors named "H Schaider"
Article Synopsis
- Keratinocyte carcinomas, like basal and squamous cell carcinomas, are common and serious issues for solid organ transplant recipients, necessitating early detection and effective treatment strategies.
- A Phase III clinical trial, called the SiroSkin trial, will assess the effectiveness of topical sirolimus in reducing skin cancer incidence among these patients compared to a placebo, involving 146 participants over 24 weeks of treatment and 18 months of follow-up.
- The trial's results aim to enhance management approaches for skin cancers in solid organ transplant recipients and gather evidence on the cost-effectiveness of using topical sirolimus.
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and this is particularly true for patients with metastatic melanoma that carry a BRAF mutation. To address this problem, we investigated cyclic membrane-active peptides as an alternative therapeutic modality to kill drug-tolerant and resistant melanoma cells to avoid acquired drug resistance. We selected two stable cyclic peptides (cTI and cGm), previously shown to have anti-melanoma properties, and compared them with dabrafenib, a drug used to treat cancer patients with the BRAF mutation.
View Article and Find Full Text PDFAims: Drivers of the drug tolerant proliferative persister (DTPP) state have not been well investigated. Histone H3 lysine-4 trimethylation (H3K4me3), an active histone mark, might enable slow cycling drug tolerant persisters (DTP) to regain proliferative capacity. This study aimed to determine H3K4me3 transcriptionally active sites identifying a key regulator of DTPPs.
View Article and Find Full Text PDFArticle Synopsis
- Skin cancer is a major global health issue, and early detection is essential for better health outcomes; 3D total-body photography is an emerging technology that aids in monitoring skin changes over time.
- The "Mind Your Moles" study aimed to understand the prevalence and development of melanocytic naevi in adults and their links to skin cancers, running from December 2016 to February 2020 with biannual participant evaluations.
- The study found that a significant percentage of participants had lesions of concern, leading to numerous referrals and diagnoses, including 39 cases of non-melanoma skin cancers and six in situ melanomas, highlighting the effectiveness of 3D imaging in identifying skin cancers.