Publications by authors named "H Savoia"
Background: The detection of deficiencies in B and folate children is important. However, despite the availability of various markers to assess B and folate metabolism, there are limited studies describing the reference intervals (RIs) and changes during growth and development for these markers in healthy children.
Methods: Using samples collected from 378 children aged 30 days-< 18 years, we derived continuous RIs for holotranscobalamin, homocysteine and red cell folate.
Hemolytic disease of the fetus and newborn (HDFN) remains an important cause of perinatal morbidity and mortality. HDFN is caused by maternal alloimmunization to red blood cell (RBC) antigens. This article describes and highlights issues in the care of pregnant women with red blood cell (RBC) alloimmunization.
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- The study examined how a major haemorrhage protocol (MHP) affects the use of blood products in children with major trauma and massive blood loss in a Melbourne pediatric trauma center.
- Over six years, 47 out of 767 major trauma patients received blood products, but none achieved the optimal 1:1:1 ratio of red blood cells, fresh frozen plasma, and platelets during any time period.
- The researchers concluded that the MHP did not significantly change blood product ratios due to the rare occurrence of massive blood loss, suggesting future research should explore treatment for coagulopathy and hypofibrinogenaemia.
The most common, severe cases of fetal and neonatal alloimmune thrombocytopenia among whites are caused by antibodies against human platelet antigen 1a (HPA-1a). The aims of this systematic review and meta-analysis are to determine the association between maternal HLA-DRB3*01:01 and: (1) HPA-1a-alloimmunization and (2) neonatal outcome in children born of HPA-1a-immunized women. A systematic literature search identified 4 prospective and 8 retrospective studies.
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