Partial Klüver-Bucy Syndrome following probably herpes simplex encephalitis.

An autopsy case of probable herpes simplex encephalitis (HSE) showed the partial Klüver-Bucy syndrome from 1 to 7 months after the onset, which consists of strong oral tendencies, emotional changes and possible hypersexuality. Several cases of the syndrome in definite or probable HSE were reviewed in this paper. In these cases including our case, the partial or complete Klüver-Bucy syndrome has appeared from some interval (2 weeks--1 month) after the acute phase, so that the syndrome should be noticed in survived or prolonged cases of HSE, as significant clinical symptoms suggesting bilateral involvement of the temporal lobes and limbic areas.

Plasma cortisol profiles in Cushing's syndrome.

Plasma cortisol profiles were studied by the frequent sampling method in 5 patients with Cushing's disease (CD), 7 patients with Cushing's syndrome due to adrenocortical adenoma (AA), and one patient with bronchogenic carcinoma. Plasma ACTH was measured by radioimmunoassay at 10 min intervals in 2 of the subjects. In CD, there was distinct episodic secretion of cortisol and ACTH; the coefficients of variation about the mean plasma cortisol concentration ranged from 24 to 27%; plasma ACTH ranged from zero to 455 pg/ml with a mean of 94 pg/ml.