Publications by authors named "H Sasada"
Article Synopsis
- * The study compared levels of OT in the hypothalamus and serum of young versus middle-aged perimenopausal female rats, finding that older rats had higher body weight and fat but similar serum OT levels.
- * The research indicates that while estrogen (E2) helps maintain serum OT levels, other factors influence OT/OT receptor levels, suggesting OT alone may not prevent weight gain or metabolic issues in perimenopausal women.
Evaluation of Deeply Infiltrating Endometriosis by Preoperative Magnetic Resonance Imaging in Patients with Adenomyosis.
Gynecol Minim Invasive Ther
December 2023
Article Synopsis
- Identifying deep infiltrating endometriosis (DIE) through preoperative MRI is crucial for assessing surgical difficulty before hysterectomy in patients with adenomyosis.
- *In a study of 54 patients, specific MRI findings were evaluated for their effectiveness in predicting DIE, with intestinal tethering and faint strands proving to be the most reliable indicators.
- *Although some findings, like a retroflexed uterus, were not helpful, others demonstrated varying levels of sensitivity and specificity, emphasizing the importance of thorough preoperative imaging.
Activin A promotes the development of endometriotic lesions in a murine model of endometriosis, and the immunohistochemical localization of phosphorylated suppressor of mothers against decapentaplegic homolog 2/3 (pSMAD2/3) complex in endometriotic lesions has been reported. Activin may therefore be involved in the development and proliferation of endometriotic cells via the SMAD signaling pathway. However, few detailed reports exist on SMAD7 expression in endometriosis.
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- Recent research shows that excess androgens in women of reproductive age can negatively impact metabolism, appetite, and body weight regulation.
- These androgens increase the risk of metabolic disorders such as obesity and diabetes by affecting appetite regulation and energy expenditure.
- However, these negative effects are not seen in post-menopausal women or ovariectomized animals, suggesting that estrogen levels might play a crucial role in how androgens influence metabolism.
The signal transducer and activator of transcription (STAT) pathway, which regulates cell proliferation and immunity, has been implicated in chronic inflammatory diseases such as rheumatoid arthritis. However, few reports have described the effects of STAT inhibitors on endometriosis, another chronic inflammatory disease. Here, we investigated the intraperitoneal microenvironment and the effects of a STAT inhibitor in a mouse model of endometriosis.
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