Publications by authors named "H Santamaria-Garcia"
Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer's disease and frontotemporal lobe degeneration from Latin America and the United States.
View Article and Find Full Text PDFCross-sectional studies suggest a limited relationship between accelerated epigenetic aging derived from epigenetic clocks, and Alzheimer's disease (AD) pathophysiology or risk. However, most prior analyses have not utilized longitudinal analyses or whole-brain neuroimaging biomarkers of AD. Herein, we employed longitudinal modeling and structural neuroimaging analyses to test the hypothesis that accelerated epigenetic aging would predict AD progression.
View Article and Find Full Text PDFArticle Synopsis
- Structural income inequality, defined as the uneven distribution of income across regions, affects brain dynamics and functions more significantly than individual factors like age or education.
- This study used EEG signals from 1,394 healthy participants across 10 countries to explore how structural inequality predicts various brain activity metrics, revealing a connection between socioeconomic conditions and neural functioning.
- Results show that higher structural income inequality is associated with lower brain signal complexity, increased random neural activity, and reduced power in certain brain wave frequencies, suggesting the need for a broader understanding of how social factors influence brain health.