Publications by authors named "H Santa"
Article Synopsis
- TP53 mutations are linked to chemoresistance in chronic lymphocytic leukaemia (CLL) and can indicate the ineffectiveness of standard chemoimmunotherapy, prompting a need for better mutation assessment.* -
- In a study of 901 CLL patients, 17.5% had TP53 mutations, with nearly half being low-burden mutations, which raises questions about their clinical significance.* -
- Low-burden TP53 mutations led to earlier treatment initiation compared to patients without mutations, suggesting the need to reconsider the detection threshold for these mutations in diagnostics.*
Background: Recent genomic studies revealed enhancer of zeste homolog 2 (EZH2) gain-of-function mutations, representing novel therapeutic targets in follicular lymphoma (FL) in around one quarter of patients. However, these analyses relied on single-site tissue biopsies and did not investigate the spatial heterogeneity and temporal dynamics of these alterations.
Objectives: We aimed to perform a systematic analysis of EZH2 mutations using paired tissue (tumor biopsies [TB]) and liquid biopsies (LB) collected prior to treatment within the framework of a nationwide multicentric study.
Purpose: Opioid misuse and overdose deaths remain a public health concern in the United States. Pennsylvania has one of the highest rates of opioid overdose deaths in the country, with Philadelphia County's being 3 times higher than the national average. Despite several multimodal interventions, including use of SBIRT (screening, brief intervention, and referral to treatment) methods and naloxone distribution, the rate of overdose deaths remains high.
View Article and Find Full Text PDF, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period.
View Article and Find Full Text PDFObjective: The purpose of this paper is to report on the implementation and evaluation of a Screening, Brief Intervention and Referral to Treatment (SBIRT) educational program into an undergraduate nursing curriculum and to recommend modifications for future trainings.
Design And Sample: A one-group pre-test/post-test design was used. The sample consisted of senior level undergraduate nursing students.