Publications by authors named "H Samaranayake"
Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study.
Ther Adv Endocrinol Metab
November 2024
Background: Diabetic foot ulcer (DFU) is a common and highly morbid complication of diabetes with high unmet medical needs. AUP1602-C, a topical four-in-one gene therapy medicinal product (GTMP), consisting of a strain that produces fibroblast growth factor-2, interleukin-4, and colony-stimulating factor-1, is a promising novel treatment for DFU.
Objectives: The aim of this first-in-human study was to investigate whether AUP1602-C is safe and effective in improving wound healing and quality of life (QoL) in patients with non-healing DFU (nhDFU), and to determine the recommended phase II dose.
Diabetes mellitus is one of the major concerns for health care systems, affecting 382 million people worldwide. Among the different complications of diabetes, lower limbs chronic ulceration is a common, severe and costly cause of morbidity. Diabetic foot ulcers are a leading cause of hospitalization in diabetic patients and its rate exceed the ones of congestive heart failure, depression or renal disease.
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- Serine hydrolases (SHs) are crucial enzymes involved in various health and disease processes, making them important targets for therapeutics, and activity-based protein profiling (ABPP) has emerged as a method to study their roles through fluorescent imaging and mass spectrometry.
- The study presented enhances ABPP by applying it to glioma brain cryosections, allowing for detailed imaging of SH activity in the tumor microenvironment while identifying specific tumor-associated cell types.
- Findings reveal increased SH activity in glioma tissues compared to normal brain, specifically highlighting the contribution of tumor-associated neutrophils over macrophages, showcasing the effectiveness of this advanced ABPP technique for studying complex biological systems.
The therapeutic efficacy of a lentiviral vector (LV) expressing the thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 14 consecutive days, resulting in reduced tumor volumes as monitored by MRI. Survival analyses revealed a significant improvement among the LV-expressing HSV-TK (LV-TK)/ganciclovir-treated animals when compared to non-treated control rats.
View Article and Find Full Text PDFBackground: Primary gestational toxoplasmosis can be transmitted to the fetus with deleterious effects on the pregnancy. There is very little information regarding gestational toxoplasmosis in Sri Lanka. This survey was done to determine the prevalence and awareness of toxoplasmosis and to identify risk factors of infection among pregnant women in the Gampaha district, Sri Lanka.
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