Publications by authors named "H Salmon"
Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attractive therapeutic targets. However, the mechanisms regulating TLS formation and maintenance in cancer are incompletely understood.
View Article and Find Full Text PDFMacroH2A has established tumour suppressive functions in melanoma and other cancers, but an unappreciated role in the tumour microenvironment. Using an autochthonous, immunocompetent mouse model of melanoma, we demonstrate that mice devoid of macroH2A variants exhibit increased tumour burden compared with wild-type counterparts. MacroH2A-deficient tumours accumulate immunosuppressive monocytes and are depleted of functional cytotoxic T cells, characteristics consistent with a compromised anti-tumour response.
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- - The study investigates "sarcopenia," age-related muscle weakness, using mice and rats to identify genetic and signaling changes that occur as muscles age.
- - Researchers analyzed the gene expression in various skeletal muscles at different ages to observe the differences between rats and mice, finding rat muscles showed greater age-related decline and unique metabolic pathway changes.
- - The results suggest that rat muscle aging may better reflect human conditions, highlighting potential targets for therapy to combat muscle decline with age.
Article Synopsis
- Inflammation is a vital immune response to harm but can become excessive, contributing to various diseases and is not completely understood at the molecular level.
- The glycoprotein CD44 helps cells take up metals like copper, which, when present in mitochondria of inflammatory macrophages, plays a crucial role in their metabolic and epigenetic changes.
- Targeting mitochondrial copper with the compound LCC-12 can reduce inflammation and alter macrophage behavior, suggesting a promising new therapeutic approach for managing inflammation and enhancing immune responses.